| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| C. Thomas Howell | The Reaper /
George Foyet |
| Meredith Monroe | Haley Hotchner |
| Christopher Cousins | Dr. Barton |
| Paul Butcher | Jeffrey Barton |
| Michael Adler | Patrick Meyers |
| D.B. Sweeney | U.S. Marshal |
| John Eddins | Detective Walker |
| Laura Niemi | Dr. Zwerling |
| Kelly Jean Clair | Principal Sheila Findlay
(as Kelly Lloyd) |
| Gary P. Stein Jr. | SWAT Commander |
| Cade Owens | Jack Hotchner |
| Norma Louise | Grieving Mother
(as Norma Hans) |
| Alexa Gonzalez | Sister #1
(uncredited) |
| Jack Schultz | Young Jeffrey Barton
(uncredited) |