| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| C. Thomas Howell | George Foyet |
| Louis Ferreira | Roy Colson
(as Justin Louis) |
| James Hanlon | Sgt. Michael O'Mara |
| James Handy | Tom Shaunessy |
| Joyce Greenleaf | Nurse |
| Frank Novak | Arthur Lanessa |
| Lynn Milano | Diane Lanessa |
| Adam Chambers | Evan Harvey |
| Cara Chute Rosenbaum | Nina Hale
(as Cara Chute) |
| Terrence Flack | Bus Driver |
| Jeffy Branion | Coroner
(as Jeff Branion) |
| Adrian Flowers | EMT |
| Jon Barton | SWAT Leader
(uncredited) |
| Keith Carr | Boston Cop
(uncredited) |
| Britt Hysen | Amanda Bertrand
(uncredited) |
| David J Law | Janitor
(uncredited) |
| Charlie Picerni | Passenger on Bus
(uncredited) |
| Tricia Trotter | Renata Jones
(uncredited) |