| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Bruce Davison | Father Davison |
| Carmen Argenziano | Father Paul Silvano |
| Walton Goggins | John Cooley |
| Roxanne Hart | Andrea Benton |
| James Remar | Tom Benton |
| Pamala Tyson | Medical Examiner |
| Dana Cuomo | Valerie |
| Joanne Ryan | Marie Valentine |
| David Sullivan | Patrick Cavanaugh |
| Jaret Sacrey | Matthew Benton |
| Weston Nathanson | Priest #1
(as Weston I. Nathanson) |
| Cliff Berens | Priest #2 |
| Michael Buonomo | Officer Lundy |
| David Mate | Brother Scott
(as David Maté) |
| Danielle Lester | Young Prentiss |
| Sean Holt | Young Matthew |
| Jon Barton | SWAT Leader
(uncredited) |
| Derek Lux | Father Paul Assistant
(uncredited) |
| Kelly Michaels | Morgue Technician
(uncredited) |
| Ian Woolf | Cab Driver
(uncredited) |