| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Sienna Guillory | Kate Joyner |
| Jack McGee | Detective Brustin |
| Erik Palladino | Detective Cooper |
| Monique Daniels | Lisa Bartleby
(as Moe Daniels) |
| Adoni Maropis | Ben Abner |
| Michael Steger | Sam |
| Amie Farrell | Shelly |
| Joe Basile | Colm Lagan |
| Greg Collins | Captain Warner |
| Loren Lester | Dr. Shore |
| Monica Young | TV News Reporter |
| Brandon Hirsch | ESU Two |
| Geoffrey M. Reeves | ESU One
(as Geoff Reeves) |
| Zac Alexander | Dr. Marino |
| Lance Strumpf | Helicopter Pilot
(uncredited) |
| Vinnie Varone | Death Row Inmate
(uncredited) |