| Joe Mantegna | David Rossi |
| Paget Brewster | Emily Prentiss |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Thomas Gibson | Aaron Hotchner |
| Nicholas Brendon | Kevin Lynch |
| Josh Stewart | William LaMontagne Jr. |
| Tia Texada | Detective Tina Lopez |
| Michael Graziadei | Steven Fitzgerald |
| Wendy Hoopes | Sarah Fitzgerald |
| David Monahan | Deacon Rogers |
| James Martin Kelly | David Fitzgerald |
| Michael Cardelle | Bus Boy
(as Michael Francis Cardelle) |
| Jacqueline Wright | Hostel Manager |
| Jeryl Prescott | Medical Examiner
(as Jeryl Prescott Sales) |
| Kara Revel | Layla |
| Douglas Barcellos | Carlos |
| Tom Sean Foley | Coordinator |
| Adrian Quinonez | Bartender #1 |
| Francesco Curá | Bar Patron
(as Francesco Cura) |
| Billy Snow | Cards Kid |
| Bruno Bruni Jr. | Hitchhiker
(as Bruno Bruni) |
| James Bannon | V
(uncredited) |
| Jon Barton | SWAT Leader
(uncredited) |
| Matthew Corbett Davis | Gay Bar Patron
(uncredited) |
| Arlo Hemphill | Miami Police Officer
(uncredited) |
| Spencer Hill | Bartender #2
(uncredited) |
| Alan Mueting | BAU Agent
(uncredited) |