| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Aisha Tyler | Dr. Tara Lewis |
| Daniel Henney | Matt Simmons |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Jane Lynch | Diana Reid |
| Michael Mosley | Everett Lynch |
| Gail O'Grady | Krystall Richards |
| Beth Riesgraf | Dr. Maeve Donovan |
| Josh Stewart | William LaMontagne Jr. |
| Stephen Bishop | Andrew Mendoza |
| Kelly Frye | Kristy Simmons |
| Page Leong | Dr. Kiyomura |
| C. Thomas Howell | George Foyet |
| Jayne Atkinson | Erin Strauss |
| Gina Garcia | Agent Garcia Sharp
(as Gina Garcia-Sharp) |
| Andre G. Ellingson | Agent Smith
(as André Ellingson) |
| Brian Appel | Agent
(uncredited) |
| Thomas Gibson | Aaron Hotchner
(archive footage) (uncredited) |
| Lola Glaudini | Elle Greenaway
(uncredited) |
| Shemar Moore | Derek Morgan
(archive footage) (uncredited) |
| Mandy Patinkin | Jason Gideon
(archive footage) (uncredited) |
| Cailan Robinson | Nurse
(uncredited) |
| Michelle Trachtenberg | Diane Turner
(archive footage) (uncredited) |
| Jeanne Tripplehorn | Alex Blake
(archive footage) (uncredited) |