| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Aisha Tyler | Dr. Tara Lewis |
| Daniel Henney | Matt Simmons |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Kim Rhodes | Assistant Director Linda Barnes |
| Casey Thomas Brown | Kevin Peck |
| Gary Basaraba | James Odenkirk |
| Jay Jackson | Cybercrimes Unit Chief Gary Omri |
| Anissa Borrego | Anita Aldo |
| Drake Hogestyn | Senator Alfred Mayhew |
| Kate Amundsen | Jessica Mayhew |
| Steve Bethers | Adam Jefferies |
| Teo Olivares | Ned Hogan |
| Laura Long | Scully Lookalike |
| William Nicol | Mulder Lookalike |
| Elle Young | Tyra |
| Victor Buno | Agent Douglas Rudy |
| Lucas Salvagno | Chad Stiller |
| Charlie E. Schmidt | Director |
| Felipe Figueroa | Concierge |
| Natalie Jongjaroenlarp | Pretty Co-Ed |
| Cottrell Guidry | Agent Sean Dougherty |
| Liana Ramirez | Victim #2 |
| Chloe Dworkin | Victim #3 |
| Nicole Alexandra Shipley | Victim #1
(as Nicole Shipley) |