| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Damon Gupton | Stephen Walker |
| Aisha Tyler | Dr. Tara Lewis |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Ivan Hernandez | Mark Tolson |
| Zachary Abel | Bill Seavers
(as Zachary Burr Abel) |
| Remington Hoffman | Wesley Parham |
| Carlos Arellano | Chief Bailor |
| Andrew Liberty | Dale Ericsson |
| Keith Antone | Nick Goode |
| Angela Gots | Kate |
| Jessy Greer | Tammy Ericsson
(as Jessica Greer) |
| David Otunga | Dwayne Jerrard |
| Amelia Alvarez | Angela Mastriano
(as Amelia Champion) |
| Helen Sadler | Diane |
| Angela Robinson Witherspoon | Cassie Campbell |
| John O'Brien | Dr. Meyer |
| Jason R. Holmes | Ben |
| John Grohl | Christian |
| Jin Maley | Reporter
(as Lisa Maley) |
| Chris Parks | Brent Miller |
| Skylar Roberge | Renee |
| Maia Schobel | Maddison Mastriano |