| Joe Mantegna | David Rossi |
| Matthew Gray Gubler | Dr. Spencer Reid
(credit only) |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Damon Gupton | Stephen Walker |
| Aisha Tyler | Dr. Tara Lewis
(credit only) |
| Adam Rodriguez | Luke Alvez |
| Paget Brewster | Emily Prentiss |
| Stevie Lynn Jones | Bea Adams |
| Jon-Michael Ecker | Zeke Daniels
(as Jon Ecker) |
| Marnee Carpenter | Kay |
| Sam Puefua | Germ |
| Sadie Kuwano | Viv
(as Sadie Schwolsky) |
| Alison Robertson | Michelle Adams |
| Neil Colin | Paul Adams |
| Esodie Geiger | M.E. Sterling |
| Tarina Pouncy | Claire Vendl |
| Thai Douglas | Joe Vendl |
| Robert J. Watkins | Crime Scene Tech
(as Robert James Watkins) |
| Tricia Cruz | Lenore Purcell |
| Joseph Will | Rick Purcell |
| Charlotte Bjornbak | Olsen Resident
(uncredited) |