| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| Gary Sinise | Jack Garrett |
| Anna Gunn | Lily Lambert |
| Daniel Henney | Matt Simmons |
| Tyler James Williams | Russ Montgomery |
| Tom Everett Scott | Greg Sullivan |
| Bonnie Somerville | Colleen Sullivan |
| Darri Ingolfsson | Jerry Tidwell |
| Sterling K. Brown | Fitz |
| Gatlin Kate James | Alison Sullivan
(as Gatlin Green) |
| Esai Morales | Section Chief Mateo Cruz |
| Newell Alexander | James Sullivan |
| Judith McConnell | Pat Sullivan |
| Andrew Miller | Nick Sullivan |
| Jakob Miller | Nick Sullivan |
| Lu Louis | Local Driver |
| Maritza Cabrera | Assistant Alisha Paun |
| Sara Montez | Trainee Charlotte Keller |
| Dylan Garza | Young Jerry Tidwell |
| Cydney Hansen | Isaac Family Victim
(uncredited) |
| Shawn Kyles | Mr. Tidwell
(uncredited) |
| Jami Platt | Mrs. Tidwell
(uncredited) |
| Isaiah Shinn | Tourist
(uncredited) |