| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| Lex Medlin | Allen Archer |
| Sarah Lafleur | Brenda Archer |
| Candace Hammer | Dylan Einstein
(as Candace Burr Scholz) |
| Grinnell Morris | James Burke |
| Merrick McCartha | Mayor |
| Luis Carazo | Tony |
| JB Tadena | Jordan Aguilar |
| Claude Knowlton | Reporter |
| Gwen Van Dam | Elderly Woman |
| Thomas W. Ashworth | Elderly Man |
| Marcus Folmar | Chef |
| Jeff Doba | Driver |
| Leticia Hirabayashi | Female Cop
(as Leticia Serrano) |
| Shauna Chin | Doctor |
| Joe Forgione | Federal Agent |
| Jordyn Schultz | Hannah Ford |
| Reverend John Atom | Indianapolis Police
(uncredited) |
| Michael Cummings | Blast Victim
(uncredited) |
| Jan M. Janssen | Grant Ford
(uncredited) |
| Heather M. Kayal | Coffee Shop Victim
(uncredited) |
| Eric Shackelford | Coffee Shop Victim
(uncredited) |