| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| Ray Abruzzo | Frank Cosgrove |
| Lindsay Pulsipher | Estelle Cosgrove |
| Amber Stevens West | Joy Struthers
(as Amber Stevens) |
| Meeghan Holaway | Cheryl Grant |
| Paul Carafotes | Dale Crawford |
| J.J. Johnston | Impatient Man |
| Russell Richardson | Thomas Scott |
| Sewell Whitney | Peter Goodwin |
| Stephan Smith Collins | Dr. Urman |
| Robert Dunne | Young David Rossi |
| Joseph H. Johnson Jr. | Young Harrison Scott |
| Elise Buedel | Carol Murray |
| Eric Almquist | Greg Murray |
| Frantz Turner | Clarence Wright |
| Sandra Cevallos | Dr. Mahaffey |
| Hilary Ward | May Scott |
| Adam Zastrow | Keith Doheny
(as Adam William Zastrow) |
| Cynthia Kania | DMV Supervisor |
| Shirley Butler | Betty Wright |
| Sean Summers | DMV Employee |
| Cooper J. Friedman | Timmy Cosgrove |
| Candace Leung | Nurse |
| Ernie Charles | Orderly |
| Willie J. Williams | General Williams |
| Tosha Lynette | DMV Customer
(uncredited) |
| Margaret Newborn | DMV Customer
(uncredited) |
| Paula Ray | DMV Customer
(uncredited) |