| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| Pamela Reed | Mary Bidwell |
| J. Michael Trautmann | John David Bidwell |
| Anjali Bhimani | Dr. Rasgotra |
| Christopher May | Rodney Tanner |
| Tatiana Turner | Ann Olson
(as Tatiana Szalay) |
| Cornelius Jones Jr. | Desmond |
| Michael Hyland | Phil Olson |
| Braden Fitzgerald | Hunter Olson |
| Billy Dec | Detective Paul Rosado |
| Shannon Lorance | Sandra Bidwell |
| Molly Baker | Jessica Brooks |
| Cade Owens | Jack Hotchner |
| Terence Bernie Hines | Stanley Holmes |
| Phylicia Wissa | Marjorie |
| Kelly Fitzgerald | Lyla Olsen |
| Anson Bagley | Joshua Parker |
| Ephraim Burns | Tyler |
| Clint Carmichael | Sam Bidwell |
| Brenda Kate | Mrs. Parker |
| Gregg Rogen | Mr. Parker |
| Travis Gibson | Jake McCauley |
| Austin Kane | Young John David Bidwell |
| John Henry | Nolan Alvarado |
| Britain Dalton | Billy Hawkins |
| Abigail Zoe Lewis | Young Sandra Bidwell |
| Dillon Fitzgerald | Child in Pumpkin Patch
(uncredited) |
| Peggy Glenn | Shopping Mall Pedestrian
(uncredited) |
| Josh Harp | Creepy Guy #2
(uncredited) |
| Clayton Jackson | Child Extra
(uncredited) |
| Natasha Kojic | Police Officer
(uncredited) |