| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| C.S. Lee | Justin Leu |
| Nicholas Brendon | Kevin Lynch |
| Potsch Boyd | Greg Baylor |
| Chris Devlin | Detective Sachs
(as Christopher Devlin) |
| Al Coronel | Mr. Connoley |
| Jimmy O. Yang | Nathan Chow |
| Ambrit Millhouse | Shanice |
| Vivian Kerr | Emily Hazley |
| Ho-Kwan Tse | Raymond Leu |
| Steven Hack | Dr. Anthony Reynolds M.E. |
| Rick Deats | Flashback Priest |
| Tom Killam | Warden |
| Blair Dickens | Guard #2 |
| Karen Furno | Widow |
| Carlos E. Campos | Baldridge Priest |
| Austin Chandra | Young Justin Leu |
| Christopher Chen | Dan Chen |
| Philip Ellis | Todd Leu |
| Brian Hill | Guy
(as Brian Alan Hill) |
| Justin Thomas Howell | Mr. Connoley's Son
(as Justin Howell) |
| Harrison Holzer | High School Student |
| Alexas Medina | Guard #1
(as Alice Medina) |
| Stephen Twardokus | Gassed Victim #1 |
| Cindy Buck | Seattle Police Detective
(uncredited) |