| Jason Beghe | Hank Voight |
| Jon Seda | Antonio Dawson |
| Sophia Bush | Erin Lindsay |
| Jesse Lee Soffer | Jay Halstead |
| Patrick John Flueger | Adam Ruzek |
| Marina Squerciati | Kim Burgess |
| LaRoyce Hawkins | Kevin Atwater |
| Amy Morton | Trudy Platt |
| Brian Geraghty | Sean Roman |
| Elias Koteas | Alvin Olinsky |
| Jeremy Davidson | Sgt. Dave Roland |
| Markie Post | Barbara 'Bunny' Fletcher |
| Samuel Hunt | Greg Gerwitz |
| Jamie Anne Allman | Linda Sovana |
| Joseph Lee Anderson | Carter Perry |
| Madison McLaughlin | Michelle Sovana |
| Robert Belushi | Landon Vanick |
| Robert Wisdom | Ron Perry |
| Patrick Gough | Aaron Jones |
| Carlo Lorenzo Garcia | Benny Lopez |
| Simeon Henderson | Reggie Barnes |
| Mark Forrest | Chief George Baumgartner |
| Ronald L. Conner | Chief Chet Harper |
| Joshua Torrez | Drugstore |
| Ron Stevens Sr. | Bang-Bang |
| David Hernandez | Cartel Frontman |
| Aira Alcantara | Girlfriend |
| Vanessa Lynch | Daughter |
| Peter A Kelly | TAC Officer Cargill |
| Joseph R. Lopez | Lawyer |
| Kathy Wolter | IAD Officer Karen O'Toole |
| Nicholas Mayer | Paramedic |
| Josh Bradshaw | Bystander |
| Franklin DeWar | Night Club Patron |
| Garret Kaminskis | Police Chief Jackson Park |
| Rafaela Ochoa | Female Club Lounge Patron |