| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Toks Olagundoye | Hayley Shipton
(credit only) |
| Jonathan Silverman | Alan Masters |
| Sunkrish Bala | Vikram Singh |
| Kristoffer Polaha | Caleb Brown |
| Kate Cobb | Gwen Parker |
| Brian Scolaro | Dave Barton |
| Maurice Benard | Horatio Spate |
| Patrick Labyorteaux | Glen Hume |
| Raymond Ma | Lucky Dragon Owner |
| Sean Holland | Uniformed Officer |
| Kenzo Lee | Mike Lin |
| Elimu Nelson | Frank Patchett |
| Jordan Borges | Lab Technician
(uncredited) |
| Marin Hinkle | Dr. Rebecca Ellins
(uncredited) |
| John William King | Fireman
(uncredited) |
| Michelle Manteris | Lab Technician
(uncredited) |