| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Toks Olagundoye | Hayley Shipton |
| James Morrison | Deputy Commissioner Malone |
| Ellen Woglom | Rachel Decker |
| Michael Bowen | Sgt. Joseph Ortiz |
| Wings Hauser | Jack Flanagan |
| Delon de Metz | Dave Chambers |
| Evan Adrian | Daniel Bardot |
| Hal Devi | Company Sergeant |
| Christina Grance | Jane Lopez |
| Andrew Hwang | Steve Takata |
| Antonio Jovani Leon | Arthur Stinson
(as Antonio Leon) |