| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle |
| Toks Olagundoye | Hayley Shipton
(credit only) |
| John Billingsley | Dr. Harvey Larson |
| Corbin Bleu | Hunter |
| Mark Famiglietti | Scott Weinberg |
| Fiona Gubelmann | Linda Weinberg |
| Joe Regalbuto | Dan O'Grady |
| Jaquita Ta'le | Charisse |
| Sonya Eddy | Olivia 'Mama' Toussaint |
| Arnell Powell | Chris Jackson |
| Miguel Cohen | Dexter Grimes |
| Anthony Ma | Emree |
| Valeria Maldonado | Agnes Molina |
| Mason McCulley | Percy Johnson III |
| Nikhil Pai | Troy Horowitz |
| Reilly Brooke Stith | Robyn King |
| Isabel Dresden | Chloe Jarvis
(uncredited) |
| Jessica Freedman | Singer
(uncredited) |
| Briana Lee | Singer
(uncredited) |
| Monica Lorayne | Acapella Member
(uncredited) |