| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish
(credit only) |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Ricardo Chavira | Congressman Alex Lopez |
| David Conrad | Frank Kelly |
| David Andrews | Carl Shelton |
| Maya Stojan | Tory Ellis |
| Charlie Hofheimer | Eric Chambers |
| Reiko Aylesworth | Mia Lopez |
| Ali Hillis | Megan Brooks |
| Heather Mazur | Gwen Kelly |
| Michael Blum | Ronald Baker |
| Daryl C. Brown | Jim Boyee |
| Stephen Howard | Harry Solberg |
| Matt Kirkwood | Attorney |
| Annie Little | Carolyn Decker |
| Edelyn Okano | Bree Colton |
| Jayde Rossi | Aryana Jones |
| Jeremy Tardy | Julian Bailey |
| Sabrina Culver | Patron
(uncredited) |
| Darwin Damian | Bartender
(uncredited) |
| Toni French | Patron
(uncredited) |