| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish
(credit only) |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Daya Vaidya | Sophia Del Cordova |
| Jackson Hurst | Harlan Mathis |
| Arye Gross | M.E. Sidney Perlmutter |
| Erick Lopez | Marcus Segundo |
| Nazneen Contractor | Layla Nasif |
| Kamar de los Reyes | Manuel Villalobos |
| Adam Wylie | Ronny |
| Franco Barberis | Francisco Herrara |
| Valorie Hubbard | Pam |
| Cindy Luna | Anahita Menendez |
| Vannessa Vasquez | Gabriela |
| Adrian Bustamante | Chris
(uncredited) |
| Josh Dean | Jim Kogut
(uncredited) |
| Christian Gehring | Conrad Hayward
(uncredited) |
| Ben D. Goldberg | Aaron Rich
(uncredited) |
| Nick Greene | Aiman Haddad
(uncredited) |
| Lisa Kaminir | Captain Edmunds
(uncredited) |
| Inbar Lavi | Farrah Darwaza
(uncredited) |
| Chris Erric Maddox | Kris
(uncredited) |
| Margaret Newborn | Pedestrian /
Driver
(uncredited) |
| Paula Newsome | Debbie Parker
(uncredited) |
| Brien Perry | Air Marshal Kyle Ford
(uncredited) |
| Maya Stojan | Tory Ellis
(uncredited) |
| Kincaid Walker | Marilyn Singer
(uncredited) |
| Roy Werner | Victor Dietrich
(uncredited) |