| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish
(credit only) |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Brittany Ishibashi | Saya Ozu |
| Arye Gross | M.E. Sidney Perlmutter |
| Ron Yuan | Michio Saito |
| Chris Bruno | Randall Bedford |
| Arden Cho | Kiara |
| Mike Moh | Lee Tong |
| Cameron Deane Stewart | Dean Bedford |
| Carin Chea | Secretary |
| Caitlin Gold | Yumi |
| Tarri Markel | Sharon Bedford |
| Anna Moon | Aiko |
| Faye Viviana | Jade Yamata |
| Momo Yashima | Mama-San |
| Billy Choi | Security
(uncredited) |
| Stephen Janousek | Businessman
(uncredited) |
| Hisato Masuyama | Businessman Singer
(uncredited) |
| Yumi Mizui | Hostess Singer
(uncredited) |