| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(credit only) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Frances Fisher | Matilda King |
| Rex Lee | Yumi |
| Rob Estes | Julian Bruckner |
| John Eric Bentley | James Kavanaugh |
| Paul Cassell | Marcus Conway |
| Brian Elerding | Armando Montoya |
| Thea Gill | Gloria Robbins |
| Denyce Lawton | Lillian Hernandez |
| Emily Wilson | Grace |
| Gina Alvarez | Teresa Gomez |
| Nadège August | Leslie
(as Nadege August) |
| Angelique Cinelu | Lola |
| Abigail Klein | Carrie |
| Danny Max | Justin |
| Jonathan Roumie | Serge Belmonde |
| Meredith Richardson | Ella Hayes
(uncredited) |
| Jonathan Stanton | Personal Assistant
(uncredited) |