| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish
(credit only) |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) (credit only) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Carlos Bernard | Jared Stack |
| Eric Lange | Simon Warburg |
| Catherine Dent | Beth Tanner |
| Shane Coffey | Sean Tanner |
| Hrach Titizian | Omar Dixon |
| Steven M. Gagnon | Colonel Fortis |
| Jeffrey Meek | Ronald Hooper |
| Amanda Tepe | Monica Lane |
| Paul Keith | Myron Mayblee |
| Jed Bernard | Agent Guerrero |
| James Stellos | Dale Tanner |