| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan /
Fenton O'Connell |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) (credit only) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Cara Buono | Siobhan O'Doul |
| Juliana Dever | Jenny Ryan |
| Benito Martinez | Special Agent Sam Walker |
| Brian Letscher | Liam Finch |
| Christina Cox | Maggie Finch |
| Michael Rodrick | Robert 'Bobby S.' Shannon |
| Jeremy Ray Valdez | Todd |
| Patrick Scott Lewis | Marcus Dunn |
| Will McFadden | Danny Keane |
| Tom Poole | Older Man Patron
(uncredited) |