| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) (credit only) |
| Penny Johnson Jerald | Captain Victoria Gates |
| Jack Coleman | Senator William H. Bracken |
| Michael Dorn | Dr. Carter Burke |
| Brett Rickaby | Robert McManus |
| Erin Krakow | Julie Rogers |
| Matt Kaminsky | Chief of Staff Evan Howard |
| David Grant Wright | Ben Moss |
| Kristin Carey | Sheila Bracken |
| Darren Dupree Washington | Security Aide |
| Aaron Norvell | Officer |
| J. Anthony McCarthy | Hotel Manager |
| Michael DiBacco | Auto Repair Shop Owner |
| Elizabeth Pan | News Reporter |
| Bryan Okes | Reporter No.2
(as Bryan Okes Fuller) |
| Hart Boykin | Homeless Man |
| Ann Hu | Audio Tech |
| Brittany Buckner | Melanie Rogers
(uncredited) |
| G. Grant Jewett | Noah Charles
(uncredited) |
| Jeremy Timmins | NYPD Bomb Squad
(uncredited) |