| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Adam J. Harrington | Brad Melville
(as Adam Harrington) |
| Tim Ransom | Max Renfro |
| Larry Sullivan | Samuel Lynchberg |
| Millicent Martin | Oona Marconi |
| Mike Faiola | Paul Morton |
| Bruce Gray | Charles Carson |
| Neil Brown Jr. | Eddie Gordon |
| Arlene Santana | Jasmine |
| Matthew Alan | Jason Bagwell |
| Shelli Boone | Chantal |
| Erin Chambers | Suzanne Steiner |
| Lauralee Bell | Pam Francis |
| Braeden Marcott | Pierre Dubois |
| Krishna Cole | Santino |
| Anna Lunberry | Jeanine |
| Karla Mosley | P.A. |
| Marisha Shine | Odette Morton
(uncredited) |