| Nathan Fillion | Richard Castle /
Joe Flynn |
| Stana Katic | Kate Beckett /
Vera Mulqueen |
| Susan Sullivan | Florence Kennard |
| Jon Huertas | Javier Esposito /
Dempsey's Cuban |
| Seamus Dever | Kevin Ryan /
Dempsey's Irishman |
| Tamala Jones | Lanie Parish /
Betsy Sinclair |
| Molly C. Quinn | Sally Scofield
(as Molly Quinn) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Mark Pellegrino | Tom Dempsey /
Tom Dempsey III |
| Chad Everett | Jerry Maddox |
| Ellen Geer | Viola Maddox |
| Patrick Cassidy | Clyde Belasco |
| Zahn McClarnon | Ray Horton |
| Lorin McCraley | West Side Wally |
| Andrea Grano | Cindy Banks |
| Adam Bay | Leonard |
| Sarah Lilly | Luella McManus |
| Darin Toonder | Frankie |
| Jared Farid Ward | Bartender
(as Jared Ward) |