| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Hilarie Burton | Kay Cappuccio |
| Justin Hartley | Reggie Starr |
| Nana Visitor | Dr. Patty Barker |
| Kevin E. West | Jack Patterson /
Teddy Wieser |
| Tommy Savas | Marcus Hiatt |
| Scott Lowell | David Hernande |
| Jim Abele | Adam Green |
| Tiffany Lowery | Phoebe |
| Ed Francis Martin | Francisco Pilar
(as Ed F. Martin) |
| Dale Waddington | Kelly Gunther |
| Robin Sachs | Announcer |
| Charles Carpenter | Reporter |
| Andre Ing | Photographer |
| Diane Modafferi | Uniform Cop |
| Corinne Blanchon | Dog Owner
(uncredited) |