| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Rick Gonzalez | Mickey Carlson |
| Sarah Joy Brown | Amanda Livingston
(as Sarah Brown) |
| Scott Elrod | Brad Dekker |
| Senta Moses Mikan | Michele Langford
(as Senta Moses) |
| Jack McGee | Dale Fickas |
| Siena Goines | Donna Vincennes |
| Christie Lynn Smith | Melanie Kopek |
| Jon Curry | Stan Kopek |
| Michael Enright | Noel Du Preez |
| Corey Mendell Parker | Reggie Dyson |
| Shania Accius | Candace Dyson |
| David Appelbaum | Morgue Assistant |
| Kortney Nash | Simone Dyson |
| Yurie Ann Cho | Hostess |
| Adrian Neil | Maitre D' |
| Jay Caputo | Antone Frances
(uncredited) |
| Wesley Sellick | Douglas Bishop
(uncredited) |