| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish |
| Seamus Dever | Kevin Ryan |
| Jayne Brook | Claudia Peterson |
| Sarah Drew | Chloe Richardson |
| George Newbern | Howard Peterson |
| Jason Brooks | Ian Harris |
| Melinda Page Hamilton | Diana Harris |
| Ken Lerner | Police attorney |
| Michael Graziadei | Brent Johnson |
| Len Lesser | Neighbour |
| Lony'e Perrine | Bethany
(as Lonyé Perrine) |
| Eamon Hunt | Frank Garrison |
| Claudia Choi | Video Technician |
| Rodney J. Hobbs | Worker |
| Ama'ri | Nanny Kid
(uncredited) |
| Mandy Kowalski | Sara Manning
(uncredited) |
| Yaron Urbas | Photographer
(uncredited) |