| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Monet Mazur | Gina Griffin |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Stephen J. Cannell | Stephen J. Cannell |
| James Patterson | James Patterson |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Dan Castellaneta | Judge Markway |
| Tamala Jones | Lanie Parish |
| Keir Dullea | Jonathan Tisdale |
| Colby French | Detective |
| Brian Avers | Harrison Tisdale |
| Kurt David Anderson | Kyle Cabot |
| Ian Jarvis | Silver Fox |
| Caitlin McHugh | Receptionist |
| Kevin Jiggetts | Uniformed Cop |
| James P. Anderson | Guest Writer
(uncredited) |
| Joey Auzenne | Cop #2
(uncredited) |
| Sara DeRosa | Giggling Girl
(uncredited) |
| Maria Diaz | Book Release Party Guest
(uncredited) |
| Kym Jackson | Allison Tisdale
(uncredited) |
| Jason Mulcahy | Elite Guest
(uncredited) |
| Stephanie Scionti | Golddigger
(uncredited) |
| Andrew Stewart-Jones | Bartender
(uncredited) |
| Antoine Von Boozier | Book Release Party Guest
(uncredited) |