| Donnie Wahlberg | Danny Reagan |
| Bridget Moynahan | Erin Reagan |
| Will Estes | Jamie Reagan |
| Len Cariou | Henry Reagan |
| Amy Carlson | Linda Reagan |
| Sami Gayle | Nicky Reagan-Boyle |
| Tom Selleck | Frank Reagan |
| Marisa Ramirez | Maria Baez |
| Vanessa Ray | Eddie Janko |
| Alex Kingston | Commander Sloane Thompson |
| Abigail Hawk | Abigail Baker |
| Steve Schirripa | Anthony Abetemarco |
| Anthony DeSando | Joey Razzano |
| Michael Drayer | Marcus Beale |
| John Scurti | Detective Harold Reed |
| Michelle Federer | Erika Ramus |
| Catherine Wolf | Aunt Sophia |
| Tony Terraciano | Jack Reagan |
| Andrew Terraciano | Sean Reagan |
| Andrew Dolan | Harold Kellen |
| Kevin Collins | Roger Thornton |
| Pallavi Sastry | Cameron |
| Danny Garcia | Officer Steve Smith |
| Max Killough | Bank Robber #1 |
| Jonathan Melo | Bank Robber #2 |
| John Weigand | Waiter |
| Christopher Akpobiyeri | Uniform |
| Vanessa Urzia | Erika's Daughter |
| Selena Nelson | Female Bank Clerk |
| Roger Brenner | NYPD |
| Richard R. Corapi | Deputy Commissioner of Operations NYPD |
| Jerry DiLeo | Police Officer |
| Larry Gregory | Chief Special Operations Division |
| Faith Logan | Teenager |
| Christopher Parker | DA Detective #2 |
| Lynne Valley | Attorney |