| Donnie Wahlberg | Danny Reagan |
| Bridget Moynahan | Erin Reagan |
| Will Estes | Jamie Reagan |
| Len Cariou | Henry Reagan |
| Amy Carlson | Linda Reagan |
| Sami Gayle | Nicky Reagan-Boyle |
| Tom Selleck | Frank Reagan |
| Marisa Ramirez | Maria Baez |
| Vanessa Ray | Eddie Janko |
| Whoopi Goldberg | City Council Speaker Regina Thomas |
| Gregory Jbara | Garrett Moore |
| Robert Clohessy | Sid Gormley |
| Abigail Hawk | Abigail Baker |
| Dakin Matthews | Judge Wilson |
| Erin Cummings | Lori D'Angelo |
| Joseph Lyle Taylor | Ronnie D'Angelo |
| Delaney Williams | Bureau Chief Dennis Egan |
| Chris Perfetti | ADA Elliot Pinsky |
| Tony Terraciano | Jack Reagan |
| Andrew Terraciano | Sean Reagan |
| Derek Roché | Paul Rossi |
| Iliana Guibert | Councilwoman Hernandez |
| Jonas Cohen | Mitchell Greer |
| Benjamin Snyder | Matthew D'Angelo |
| Anthony Robert Grasso | Sergeant |
| Byron Clohessy | Uniform |
| Kenya Brome | Defense Lawyer |
| Matthew C. Flynn | Bill Donnelly |
| Thomas Soltys | Matthew's Friend |
| Rick Younger | Councilwoman Lewis |
| Roger Brenner | NYPD |
| Peter Conboy | New York City Police Officer |
| Melanie Evans | Young DA |
| Bobby Knudsen | Assistant District Attorney |
| Faith Logan | Teenager |
| Jesse VanDerveer | Child in School Playground |
| Alex Ziwak | Undercover Detective |