| Donnie Wahlberg | Danny Reagan |
| Bridget Moynahan | Erin Reagan |
| Will Estes | Jamie Reagan |
| Len Cariou | Henry Reagan |
| Tom Selleck | Frank Reagan |
| Amy Carlson | Linda Reagan |
| Sami Gayle | Nicky Reagan-Boyle |
| Nicholas Turturro | Sgt. Anthony Renzulli |
| Gregory Jbara | Garrett Moore |
| Marisa Ramirez | Maria Baez |
| Robert Clohessy | Sid Gormley |
| Kamar de los Reyes | Santana |
| Ana Nogueira | Nona Palmeira |
| Joanna Gleason | Grace Newhouse |
| Juan Carlos Hernández | Raul |
| Robert Prescott | Detective Crockett |
| Curtiss Cook | Detective Jones |
| Tony Terraciano | Jack Reagan |
| Andrew Terraciano | Sean Reagan |
| John Rue | Ed Hines |
| Victor Slezak | Bryce Helfond |
| Omar Maskati | Hector Santiago |
| Abigail Hawk | Abigail Baker |
| Joselin Reyes | Valerie |
| Adrian Alvarado | Jorge |
| David Ramsey | Mayor Carter Poole |
| Veronica Cruz | Marina Santiago |
| Gameela Wright | Reporter #2 |
| Brian Adam DeJesus | Orlando |
| Gabe Doran | Corrections Officer |
| Gabriel Gutierrez | Carlos Villalobos |
| Randall McNeal | Dr. Jack Heller |
| Pernell Walker | Medic |
| Heather Eger | High Ranking City Official |
| Diane Guerrero | Carmen |
| Rory Duffy | Uniform 1 |
| Alexis Suarez | Uniform 2 |
| Albert Christmas | Uniform 3 |
| Glenn Alba | NYPD-ESU Officer |
| Sucen Amirak Nallem | Bitterman Housing Resident |
| Josephine Pizzino | Angry Community Member |
| Yeuris Taveras | Bitterman Housing Resident |
| Alex Ziwak | Undercover Detective |