| Reese Witherspoon | Madeline Martha Mackenzie |
| Nicole Kidman | Celeste Wright |
| Shailene Woodley | Jane Chapman |
| Laura Dern | Renata Klein |
| Zoë Kravitz | Bonnie Carlson |
| Adam Scott | Ed Mackenzie |
| James Tupper | Nathan Carlson |
| Jeffrey Nordling | Gordon Klein |
| Kathryn Newton | Abigail Carlson |
| Iain Armitage | Ziggy Chapman |
| Alexander Skarsgård | Perry Wright |
| Meryl Streep | Mary Louise Wright |
| Darby Camp | Chloe Mackenzie |
| Cameron Crovetti | Josh Wright |
| Nicholas Crovetti | Max Wright |
| Martin Donovan | Martin Howard |
| Merrin Dungey | Detective Adrienne Quinlan |
| Crystal Fox | Elizabeth Howard |
| Ivy George | Amabella Klein |
| Denis O'Hare | Ira Farber |
| Douglas Smith | Corey Brockfield |
| Robin Weigert | Dr. Amanda Reisman |
| Christopher Backus | Joe |
| Larry Bates | Stu |
| Nelly Buchet | Juliette |
| Gia Carides | Melissa |
| Chloe Coleman | Skye Carlson |
| Kelen Coleman | Harper Stimson |
| Eve Gordon | Dr. Danielle Cortland |
| Lola Langusta | Disco DJ |
| John Marshall Jones | John Davidson |
| Preston Mui | Choreographer |
| Bruce Nozick | Walter Ruttenberg |
| Jeryl Prescott | Cecilia |
| Joel Spence | Matt |
| Larry Sullivan | Oren Berg |
| Earl Young | Earl Young
(as Earl D. Young) |
| Antwon M. Young | The Trammps |
| Lorenzo Rankins | The Trammps |
| Adrian L. Jackson | The Trammps |
| Santiago Cabrera | Joseph Bachman
(archive footage) |
| Mia Coleman | School Child |
| Gregory Garcia | Dancer |
| Khalilah Joi | Young Elizabeth |
| Benjamin Valic | Looping
(voice) |
| Violet Raine McMahan | Young Renata Klein
(uncredited) |
| Heather Simpson | Helen
(uncredited) |