| Reese Witherspoon | Madeline Martha Mackenzie |
| Nicole Kidman | Celeste Wright |
| Shailene Woodley | Jane Chapman |
| Laura Dern | Renata Klein |
| Zoë Kravitz | Bonnie Carlson |
| Adam Scott | Ed Mackenzie |
| James Tupper | Nathan Carlson |
| Jeffrey Nordling | Gordon Klein |
| Kathryn Newton | Abigail Carlson |
| Iain Armitage | Ziggy Chapman |
| Alexander Skarsgård | Perry Wright |
| Meryl Streep | Mary Louise Wright |
| P.J. Byrne | Principal Warren Nippal |
| Darby Camp | Chloe Mackenzie |
| Nicholas Crovetti | Max Wright |
| Cameron Crovetti | Josh Wright |
| Merrin Dungey | Detective Adrienne Quinlan |
| Crystal Fox | Elizabeth Howard |
| Ivy George | Amabella Klein |
| Mo McRae | Michael Perkins |
| Douglas Smith | Corey Brockfield |
| Robin Weigert | Dr. Amanda Reisman |
| Gia Carides | Melissa |
| Chloe Coleman | Skye Carlson |
| Kelen Coleman | Harper Stimson |
| Mykal-Michelle Harris | Young Bonnie |
| Khalilah Joi | Young Elizabeth |
| Kerri Kenney | Dr. Belinda Shea |
| Sunday Rose Kidman-Urban | School Child |
| Faith Margaret Kidman-Urban | School Child |
| Lauren Lakis | Yvonne |
| Michael Laskin | Dr. Howard Feldman |
| Asher McDonell | 3-Year-Old Max |
| Brayden McDonell | 3-Year-Old Josh |
| Eliza Shin | Vice Principal Coolidge |
| Joel Spence | Matt |
| Larry Sullivan | Oren Berg |
| Jessica Villalba | Nurse |
| Alan Godshaw | Concerned Parent |
| Mark Heidelberger | Concerned Parent |
| Larisa Kazanskaya | Concerned Parent |
| Michelle Lenhardt | Concerned Parent |
| Talon Tears | Concerned Parent |
| Santiago Cabrera | Joseph Bachman |
| Gregory Garcia | Concerned Parent |
| Jonathan Grebe | EMT |
| Jeni Jones | Parent |
| Luke Matheis | Parent |
| Veronika Mindal | Parent |