| Dwayne Johnson | Spencer Strasmore |
| John David Washington | Ricky Jerret |
| Omar Benson Miller | Charles Greane |
| Donovan W. Carter | Vernon Littlefield |
| Troy Garity | Jason |
| London Brown | Reggie |
| Jazmyn Simon | Julie Greane |
| Arielle Kebbel | Tracy Legette |
| Rob Corddry | Joe Krutel |
| Andy Garcia | Andre Allen |
| Dulé Hill | Larry Siefert |
| Richard Schiff | Mr. Anderson |
| Robert Wisdom | Dennis |
| Okieriete Onaodowan | Anthony |
| Tiffany Jeneen | Virginia |
| Stacy Ann Rose | Dr. Robbins |
| Anthony Adams | Anthony 'Spice' Adams |
| Jared Odrick | Jared Odrick |
| Garth Henry | Nate |
| Andrew Rosenberg | Dale |
| Shalim Ortiz | Manny |
| Joseph Barrios | Dude |
| Nhya Cedon | Woman |
| Giana Basillo | University Student |
| Tamila Bilalova | Girlfriend of a Football Player |
| Margaret Bishop | Business Woman |
| Courtney Brown | Frat Boy |
| Xavier Cortes | Cameraman |
| Gary Cudney | Fashion Show Guest |
| Ellen Marguerite Cullivan | Hospital Waiting Room Visitor |
| Christopher De Stefano | University of Georgia Professor |
| Safi El Masri | Recurring Suit Shop Tailor |
| Ricardo Finnis | Hospital Orderly |
| Frenchi Firecracker | Midwestern Airline Passenger |
| Patrick H. Fox | Midwestern Airline Passanger |
| Christina Hammoud | Yacht Model |
| Alona Leoine | Football Player's Kid |
| Roselyn Medrano | Stripper |
| Mason Mills | Traveler |
| Crystal-Lee Naomi | Woman |
| Harry Pearce | University Student |
| Ned Smith | Waiting Room Patient |
| Dawn Soleri | Strip Club Lady |
| Mary Lisa Speer | Midwestern Airline Passenger |
| Frank Tedesco | Photographer |
| Gowon Walker | Oakland Raiders NFL Rookie |