| Jason Bateman | Michael Bluth |
| Portia de Rossi | Lindsay Bluth Fünke
(credit only) |
| Will Arnett | Gob Bluth
(credit only) |
| Michael Cera | George-Michael Bluth
(credit only) |
| Alia Shawkat | Maeby Fünke |
| Tony Hale | Buster Bluth
(credit only) |
| David Cross | Tobias Fünke |
| Jeffrey Tambor | George Bluth Sr. /
Oscar Bluth |
| Jessica Walter | Lucille Bluth
(credit only) |
| Henry Winkler | Barry Zuckerkorn |
| Ron Howard | Ron Howard /
Narrator |
| Scott Baio | Bob Loblaw |
| Judy Greer | Kitty Sanchez |
| Seth Rogen | Young George Bluth |
| Kristen Wiig | Young Lucille Bluth |
| Isla Fisher | Rebel Alley |
| Carl Weathers | Carl Weathers |
| James Lipton | Warden Stefan Gentles |
| Andy Richter | Andy Richter /
Rocky Richter |
| Brian Grazer | Brian Grazer |
| Conan O'Brien | Conan O'Brien |
| Louisa Velis | Luisa Velez |
| Maria Bamford | Debrie Bardeaux |
| Allan Wasserman | Herb Zuckerkorn |
| Liza Minnelli | Lucille Austero |
| Andrew Santino | Employer |
| Rick Federman | Prosecuting Attorney |
| Sara Chase | Receptionist |
| Barry Wiggins | Actor Portraying Carl Weathers |
| Stephanie Coffey | Andy's Stylist |
| Keeshan Giles | Imagine Guard |
| Andrew Secunda | Process Server |
| Max Winkler | Young Barry Zuckerkorn |
| Peter John Kousakis | Mike Dawkins
(as Peter Kousakis) |
| Constantine Salavas | Charles Dawkins |
| Kevin J. Walsh | Pitch Man
(as Kevin Walsh) |
| Jayme Ratzer | OC Nurse |
| Beth Melewski | Patient's Mother |
| Hamish Clark | Band Leader |
| Tristan Tierce | Red Head Pre-Teen |
| Kimberly Cash | Make Up Artist
(uncredited) |
| John Krasinski | Jerry Bruckheimer's Assistant
(uncredited) |