| Jason Bateman | Michael Bluth |
| Portia de Rossi | Lindsay Bluth Fünke |
| Will Arnett | Gob Bluth |
| Michael Cera | George-Michael Bluth |
| Alia Shawkat | Maeby Fünke |
| Tony Hale | Buster Bluth |
| David Cross | Tobias Fünke |
| Jeffrey Tambor | George Bluth Sr. /
Oscar Bluth |
| Jessica Walter | Lucille Bluth |
| Ben Stiller | Tony Wonder |
| Mo Collins | Starla |
| Ian Roberts | Literal Doctor |
| Dan Castellaneta | Dr. Stein |
| John Beard | John Beard |
| Paul Feig | Magician |
| Kevin Heffernan | Announcer |
| George Cheung | Asian Man
(as George Kee Cheung) |
| Charlie Hartsock | Ted |
| David McMillan | Doctor #1 |
| Bob Glouberman | Doctor #2 |
| Ben Hoffman | FBI Guy #1 |
| Craig Anstett | FBI Guy #2 |
| Andrea M. Anderson | Candida
(uncredited) |
| Ron Howard | Narrator
(voice) (uncredited) |