| Jason Bateman | Michael Bluth |
| Portia de Rossi | Lindsay Bluth Fünke |
| Will Arnett | Gob Bluth |
| Michael Cera | George-Michael Bluth |
| Alia Shawkat | Maeby Fünke |
| Tony Hale | Buster Bluth |
| David Cross | Tobias Fünke |
| Jeffrey Tambor | George Bluth Sr. /
Oscar Bluth |
| Jessica Walter | Lucille Bluth |
| Henry Winkler | Barry Zuckerkorn |
| Malik Yoba | Ice |
| Mae Whitman | Ann Veal |
| Jason Aaron Tinero | Young Buster |
| Abraham Higginbotham | Gary |
| Charles Canzoneri | Bluth Company Employee
(uncredited) |
| Ron Howard | Narrator
(voice) (uncredited) |
| Lucy Schwartz | Girl In George Michael's Band
(uncredited) |