| Edgar Ramírez | Gianni Versace |
| Darren Criss | Andrew Cunanan |
| Ricky Martin | Antonio D'Amico |
| Penélope Cruz | Donatella Versace |
| Dascha Polanco | Detective Lori Wieder |
| Will Chase | Detective Paul Scrimshaw |
| Jay R. Ferguson | FBI Agent Keith Evans |
| José Zúñiga | Detective George Navarro |
| Christine Horn | FBI Agent Talarah Gruber |
| Max Greenfield | Ronnie |
| Joe Adler | Jerome |
| Annaleigh Ashford | Elizabeth Cote |
| Giovanni Cirfiera | Santo Versace |
| Vincenzo Amato | Versace Spokesman |
| Cathy Moriarty | Vivian Oliva |
| Bee-Be Smith | Doctor |
| Casey Adams | Ambulance Driver |
| Jerry O'Donnell | Barreto |
| Luke Albright | Cameraman |
| Laurine Price | Countess |
| Naomi Matsuda | Dr. Emma Lew |
| Caleb Foote | Eli |
| Chic Daniel | FBI Head of Violent Crimes |
| Scott Bray | FBI Senior Agent #1 |
| Travis Myers | FBI Senior Agent #2 |
| Khotan Fernandez | Lazaro Quintana |
| Greg Pitts | Middle Aged Man |
| Peggy Blow | Miriam |
| Noelquis Rodriguez | News Anchor |
| Oscar Corbella | News Café Owner |
| Eduardo Ibarrola | News Kiosk Owner |
| Judith Remekie | News Reporter |
| Brett Edwards | Officer |
| Gregg Henry | Old Man |
| Dutch Johnson | Paramedic |
| Christine Allocca | Patrol Officer #1 |
| Charles Maceo | Patrol Officer #2 |
| Scott Broderick | Patrol Officer #3 |
| Alejandro Posada | Patrol Officer #4 |
| Arriane Alexander | Patrol Officer #8 |
| Nico Evers-Swindell | Phil |
| Joseph Barrios | Polaroid Man |
| Emil Beheshti | Surgeon #1 |
| Victor J. Ho | Surgeon #2 |
| Sally Shamrell | Surgeon #3 |
| Levon Rector | SWAT Officer #1 |
| Courtney Grant | SWAT Officer #2 |
| Lili Wexu | Tourism Rep |
| Mike Pusateri | Zabrowski |
| Chuck Ashworth | Police Officer |
| Kevyn Bashore | Male Opera Patron |
| Brent Bernhard | Motorcycle Paparazzi |
| Keith Betts | Beachgoer |
| Debra Cohen | Middle Age Woman |
| Ralph Cole Jr. | Mortician |
| Ellen Marguerite Cullivan | Homeless |
| Rachel Daigh | Nurse |
| Adam Dormi | Versace Model |
| Richard Funston | Fashion Photographer |
| Joseph Giambrone | Gay Man on Beach |
| Leigh Green | Nurse |
| Travis Grenke | Police Officer |
| Holly Kaplan | Dog Walker |
| Nicola Lambo | HSN Presenter Terry Mason |
| Kevin Lapham | Detective |
| David W. LeBlanc | Upscale Versace Friend |
| Henry LeBlanc | Older Gay Man |
| Eduardo Lezcano | Male Couple Gay Club |
| Vincent Lionetti | High Society Guest |
| John Archer Lundgren | Homeless Beggar |
| Regina McKee Redwing | Amex Operator |
| Robert Milar | Male Couple Gay Club |
| Ray Morales | Male Staff Member |
| Ryan Murphy | Versace personal body guard |
| Lynne Oropeza | TV Studio Crew |
| Omar Pederzoli | Café News Waiter |
| Brent Pope | Porter |
| Erick Szot | News Van driver |
| Romeo Visca | Donatella's Bodyguard |
| David Weiss | Frank Scottolini |
| Valdez Williams | Beachgoer |
| Matthew Woodward | Burley Stage Hand |