| Dominic West | Det. James 'Jimmy' McNulty |
| Reg E. Cathey | Norman Wilson |
| John Doman | Acting Commissioner William A. Rawls |
| Aidan Gillen | Mayor Thomas 'Tommy' Carcetti |
| Clark Johnson | City Editor Augustus 'Gus' Haynes |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Tom McCarthy | Scott Templeton |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Dep. Comm. for Operations Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Thomas 'Herc' Hauk |
| Michael Kenneth Williams | Omar Little |
| Gbenga Akinnagbe | Chris Partlow |
| Jamie Hector | Marlo Stanfield |
| Neal Huff | Chief of Staff Michael Steintorf |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Corey Parker Robinson | Det. Leander Sydnor |
| Tristan Mack Wilds | Michael Lee |
| Michael Kostroff | Maurice 'Maury' Levy |
| Michelle Paress | Alma Gutierrez |
| Isiah Whitlock Jr. | State Sen. R. Clayton 'Clay' Davis |
| Jim True-Frost | Roland 'Prez' Pryzbylewski |
| Peter Gerety | Judge Daniel Phelan |
| Amy Ryan | Off. Beatrice 'Beadie' Russell |
| Paul Ben-Victor | Spiros 'Vondas' Vondopoulos |
| Bill Raymond | The Greek |
| Delaney Williams | Sgt. Jay Landsman |
| Marlyne Barrett | Council President Nerese Campbell |
| Steve Earle | Walon |
| Ptolemy Slocum | Business Card Homeless Man |
| Maria Broom | Marla Daniels |
| David Costabile | Managing Editor Thomas Klebanow |
| Sam Freed | Executive Editor James C. Whiting III |
| Anwan Glover | Slim Charles |
| Hassan Johnson | Roland 'Wee-Bey' Brice |
| Method Man | Melvin 'Cheese' Wagstaff |
| Dion Graham | State's Attorney Rupert Bond |
| Thomas J. McCarthy | State Editor Tim Phelps |
| Robert Poletick | Metro Editor Steven Luxenberg |
| Michael Willis | Andy Krawczyk |
| Donald Neal | Rewrite Man Jay Spry |
| Kara Lee Duncan | Regional Affairs Editor Rebecca Corbett |
| Brandon Young | Mike Fletcher |
| William F. Zorzi | Bill Zorzi |
| Al Brown | Commissioner Stanislaus Valchek |
| Edward T. Norris | Det. Edward Norris |
| Michael Salconi | Off. Michael 'Sanny' Santangelo |
| Brian Anthony Wilson | Det. Vernon Holley |
| Megan Anderson | Jen Carcetti |
| Benay Berger | FBI Supervisor Amanda Reese |
| Eisa Davis | Bubbles' Sister |
| Susan Duvall | Assistant Principal Marcia Donnelly |
| Wendy Grantham | Shardene Innes |
| Bobby J. Brown | Off. Bobby Brown |
| Dennis Hill | Det. Christeson |
| Doug Olear | FBI Spec. Agent Terrance 'Fitz' Fitzhugh |
| Rick Otto | Off. Kenneth Dozerman |
| Gregory L. Williams | Det. Michael Crutchfield |
| Thuliso Dingwall | Kenard |
| Dave Ettlin | Dave Ettlin |
| Edward Bernard Green Jr. | Spider |
| Kwame Patterson | 'Monk' Metcalf |
| Stephen Schnetzer | Robert Ruby |
| Carl Schoettler | Carl Schoettler |
| William Joseph Brookes | Lawrence Butler |
| Sho Brown | Phil Boy |
| Norris Davis | Vinson |
| Reggie Alvin Green | Arabber |
| Joey Odoms | Corner Boy |
| Troj Strickland | Ricardo 'Fat Face Rick' Hendrix |
| Connor Aikin | Jack Russell |
| Sophia Ayoud | Cary Russell |
| Gary D'Addario | Grand Jury Prosecutor Gary DiPasquale |
| Clinton 'Shorty' Buise | Clinton 'Shorty' Buise |
| Henry Carter | Man |
| Alan V. Poulson | Developer |
| Dionne Audain | Social Worker |
| Chris Kies | Petey |
| Stephen Kinigopoulos | Officer |
| Edward C. Lewis | Man |
| George Smith | Man |
| Jeff Wincott | Johnny Weaver |
| Michael Ahl | Detective |
| Christopher Allison | Drug Dealer #1 |
| Ted Borodaeff | Boyfriend of William Rawls |
| Anthony Bosco | The Sun Copy Editor |
| Larry Carter | Reporter |
| Vicki Jean Clark | Banquet Attendee |
| Kristine Cornils | Lawyer |
| Tom Cutler | Detective |
| Dave Ehrman | Researcher |
| Tom Gambrill | Retired Detective |
| Art Hall | Reporter |
| Gina Hernandez | On-Air Reporter |
| Glenn Klavans | Homicide Detective |
| Marcus LaRon | Police Officer |
| Tony Moore | Attorney |
| Douglas Nelson | Homicide Detective |
| Stefan Niemczyk | Baltimore Police Officer |
| Karl Otter | District Commander |
| Jennifer Rouse | Whiting's Secretary |
| Gary 'D. Reign' Senkus | Frog |
| David Simon | Sun Staff Member |
| Ben Solenberger | Carcetti Detail |
| Al Sotto | Deli Delivery Boy |
| Thomas W. Stewart | Banquet Attendee |
| Patrick Michael Strange | Reporter |
| Katrinka Stringfield | Homicide Secretary |
| Tommy Lee Taylor Jr. | Lester Sanders |