| Dominic West | Det. James 'Jimmy' McNulty |
| Reg E. Cathey | Norman Wilson |
| John Doman | Acting Commissioner William A. Rawls |
| Aidan Gillen | Mayor Thomas 'Tommy' Carcetti |
| Clark Johnson | City Editor Augustus 'Gus' Haynes |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Tom McCarthy | Scott Templeton |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Dep. Comm. for Operations Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Thomas 'Herc' Hauk |
| Michael Kenneth Williams | Omar Little |
| Gbenga Akinnagbe | Chris Partlow |
| Jamie Hector | Marlo Stanfield |
| Neal Huff | Chief of Staff Michael Steintorf |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Corey Parker Robinson | Det. Leander Sydnor |
| Tristan Mack Wilds | Michael Lee |
| Michael Kostroff | Maurice 'Maury' Levy |
| Michelle Paress | Alma Gutierrez |
| Isiah Whitlock Jr. | State Sen. R. Clayton 'Clay' Davis |
| Peter Gerety | Judge Daniel Phelan |
| Pablo Schreiber | Nick Sobotka |
| Maestro Harrell | Randy Wagstaff |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Anwan Glover | Slim Charles |
| Method Man | Melvin 'Cheese' Wagstaff |
| Delaney Williams | Sgt. Jay Landsman |
| William Joseph Brookes | Lawrence Butler |
| Shamika Cotton | Raylene Lee |
| Brian Anthony Wilson | Det. Vernon Holley |
| Michael Willis | Andy Krawczyk |
| David Costabile | Managing Editor Thomas Klebanow |
| Sam Freed | Executive Editor James C. Whiting III |
| Nancy Grace | Nancy Grace |
| Dion Graham | State's Attorney Rupert Bond |
| Sho Brown | Phil Boy |
| Chris Clanton | Savino Bratton |
| Kwame Patterson | 'Monk' Metcalf |
| Troj Strickland | Ricardo 'Fat Face Rick' Hendrix |
| Robert Poletick | Metro Editor Steven Luxenberg |
| Scott Shane | Scott Shane |
| Brandon Young | Mike Fletcher |
| William F. Zorzi | Bill Zorzi |
| Luray Cooper | Nathaniel 'Nat' Coxson |
| Aubrey Deeker Hernandez | Terry Hanning |
| Roscoe Orman | Off. Oscar Requer |
| Richard Pelzman | Little Big Roy |
| Dionne Audain | Social Worker |
| Dave Ettlin | Dave Ettlin |
| Crissandra Spencer | Reporter |
| Ken Ulman | Reporter |
| Russ Widdall | Ron Lowenthal |
| Rasheila Daniels | Man |
| Reginald Gilmer | Man |
| Carlos Juan Gonzalez | Man |
| Neerja Sharma | Woman Interviewed |
| Jeffrey Wendell Moffatt | Stanfield Muscle |
| Michael Ahl | Detective |
| Megan Anderson | Jen Carcetti |
| Mike D. Anderson | Ghost |
| Zach Book | The Sun Graphics Designer |
| Larry Carter | Reporter |
| Dave Ehrman | Researcher |
| Cyrus Farmer | Devar Manigault |
| Art Hall | Reporter |
| Donald Neal | Rewrite Man Jay Spry |
| Edward T. Norris | Det. Edward Norris |
| Jennifer Rouse | Whiting's Secretary |
| Patrick Michael Strange | Reporter |