| Dominic West | Det. James 'Jimmy' McNulty |
| Reg E. Cathey | Norman Wilson |
| John Doman | Acting Commissioner William A. Rawls |
| Aidan Gillen | Mayor Thomas 'Tommy' Carcetti |
| Clark Johnson | City Editor Augustus 'Gus' Haynes |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Tom McCarthy | Scott Templeton |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Dep. Comm. for Operations Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Thomas 'Herc' Hauk |
| Michael Kenneth Williams | Omar Little |
| Gbenga Akinnagbe | Chris Partlow |
| Jamie Hector | Marlo Stanfield |
| Neal Huff | Chief of Staff Michael Steintorf |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Corey Parker Robinson | Det. Leander Sydnor |
| Tristan Mack Wilds | Michael Lee |
| Michael Kostroff | Maurice 'Maury' Levy |
| Michelle Paress | Alma Gutierrez |
| Isiah Whitlock Jr. | State Sen. R. Clayton 'Clay' Davis |
| Paul Ben-Victor | Spiros 'Vondas' Vondopoulos |
| Amy Ryan | Off. Beatrice 'Beadie' Russell |
| Callie Thorne | Elena McNulty |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Glynn Turman | Former Mayor Clarence V. Royce |
| Steve Earle | Walon |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Marlyne Barrett | Council President Nerese Campbell |
| Dion Graham | State's Attorney Rupert Bond |
| Delaney Williams | Sgt. Jay Landsman |
| David Costabile | Managing Editor Thomas Klebanow |
| Sam Freed | Executive Editor James C. Whiting III |
| Robert Poletick | Metro Editor Steven Luxenberg |
| William F. Zorzi | Bill Zorzi |
| Larry Andrews | Donnie |
| Darrell Britt-Gibson | Darius 'O-Dog' Hill |
| Norris Davis | Vinson |
| Kwame Patterson | 'Monk' Metcalf |
| Thomas J. McCarthy | State Editor Tim Phelps |
| Scott Shane | Scott Shane |
| Brian Anthony Wilson | Det. Vernon Holley |
| Brandon Young | Mike Fletcher |
| Fran Boyd | Nurse |
| Keenon Brice | Aaron 'Bug' Manigault |
| Thuliso Dingwall | Kenard |
| Brendan Walsh | Brendan Walsh |
| Larry Young | Shark |
| Antonio Cordova | Michael McNulty |
| Arthur Laupus | Appointment Homeless Man |
| Eric G. Ryan | Sean McNulty |
| Ptolemy Slocum | Business Card Homeless Man |
| Tony Small | |
| John E. Fairley | Man |
| Joe Hansard | Nathan Levi Boston |
| Theodore M. Snead | Sports Editor |
| Tony Tsendeas | Homeless Man #2 |
| Alexandra Tydings | Arts Editor |
| Michael Ahl | Detective |
| Zach Book | The Sun Graphics Designer |
| Anthony Bosco | The Sun Copy Editor |
| Larry Carter | Reporter |
| Vicki Jean Clark | Bar Patron |
| Dave Ehrman | Researcher |
| Edward Bernard Green Jr. | Spider |
| Art Hall | Reporter |
| Chad Ridgely | Justin Cook |
| Jennifer Rouse | Whiting's Secretary |
| Thomas W. Stewart | Bar Patron |
| Patrick Michael Strange | Reporter |
| Tom Townsend | Grand Juror |