| Dominic West | Off. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Frankie Faison | Commissioner Ervin H. Burrell |
| Aidan Gillen | Councilman Thomas 'Tommy' Carcetti |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Maj. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Howard 'Bunny' Colvin |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Sgt. Thomas 'Herc' Hauk |
| Reg E. Cathey | Norman Wilson |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Glynn Turman | Mayor Clarence V. Royce |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Maestro Harrell | Randy Wagstaff |
| Julito McCullum | Namond Brice |
| Tristan Mack Wilds | Michael Lee |
| Gbenga Akinnagbe | Chris Partlow |
| Robert F. Chew | Joseph 'Proposition Joe' Stewart |
| Tray Chaney | Malik 'Poot' Carr |
| Melanie Nicholls-King | Cheryl |
| Delaney Williams | Sgt. Jay Landsman |
| Davon Cooper | Darnell Tyson |
| Elijah Grant Johnson | Elijah |
| Taylor King | Zenobia Dawson |
| Jason Wharton | Albert Stokes |
| Tyrell Baker | Little Kevin |
| Anwan Glover | Slim Charles |
| Alfonso Christian Lover | Old Face Andre |
| Ramon Rodriguez | Renaldo |
| Stacie Davis | Ms. Duquette |
| Dan De Luca | David Parenti |
| Susan Duvall | Assistant Principal Marcia Donnelly |
| Richard Hidlebird | Principal Claudell Withers |
| Marlyne Barrett | Council President Nerese Campbell |
| Cyrus Farmer | Devar Manigault |
| Dion Graham | State's Attorney Rupert Bond |
| Frederick Strother | State Delegate Odell Watkins |
| Keenon Brice | Aaron 'Bug' Manigault |
| Nathan Corbett | Donut |
| Dravon James | Grace Sampson |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Benjamin Busch | Off. Anthony Colicchio |
| Shenia Hatchett | Woman |
| Rick Otto | Off. Kenneth Dozerman |
| Rico Sterling | Calvin |
| Bobby J. Brown | Off. Bobby Brown |
| Joe DiBlassi | Man |
| David E. Goodman | Budget Director |
| Thomas C. Hessenauer | Middle School Teacher |
| Karen Vicks | Gerry |
| Michael Ahl | Detective |
| Joanna Becker | Resturant Patron |
| Al Brown | Maj. Stanislaus Valchek |
| Stephanie Burden | Judy Pryzbylewski |
| Enrique Chicas | Bailiff |
| Michael Coley | Kwame |
| Brandi L. Davis | Nancine Nance Owens |
| Thuliso Dingwall | Kenard |
| Barney Fitzpatrick | B.D.C. President |
| Misty Kelley | Teacher |
| Jeffrey Lorenzo | Karim Williams |
| David L. Marston | Restaurant Patron |
| Amber Nelson | Miss Thiessen |
| Nicole Pettis | Miss Reese |
| Christina Pitrelli | Teacher |
| Rachel Rhodes | Hostess |
| Imani Nia Robinson | Myisha |
| Ryan Sands | Off. Lloyd 'Truck' Garrick |
| Tanesha | Ford |
| Kimelia Weathers | Restaurant Patron |
| Yan Xi | Waitress |