| Dominic West | Off. James 'Jimmy' McNulty |
| John Doman | Dep. Comm. for Operations William A. Rawls |
| Frankie Faison | Commissioner Ervin H. Burrell |
| Aidan Gillen | Councilman Thomas 'Tommy' Carcetti |
| Deirdre Lovejoy | Asst. State's Atty. Rhonda Pearlman |
| Clarke Peters | Det. Lester Freamon |
| Wendell Pierce | Det. William 'Bunk' Moreland |
| Lance Reddick | Maj. Cedric Daniels |
| Andre Royo | Reginald 'Bubbles' Cousins |
| Sonja Sohn | Det. Shakima 'Kima' Greggs |
| Jim True-Frost | Roland 'Prez' Pryzbylewski |
| Robert Wisdom | Howard 'Bunny' Colvin |
| Seth Gilliam | Sgt. Ellis Carver |
| Domenick Lombardozzi | Det. Thomas 'Herc' Hauk |
| Reg E. Cathey | Norman Wilson |
| Chad L. Coleman | Dennis 'Cutty' Wise |
| Jamie Hector | Marlo Stanfield |
| Glynn Turman | Mayor Clarence V. Royce |
| J.D. Williams | Preston 'Bodie' Broadus |
| Michael Kenneth Williams | Omar Little |
| Corey Parker Robinson | Det. Leander Sydnor |
| Richard DeAngelis | Col. Raymond Foerster |
| Jermaine Crawford | Duquan 'Dukie' Weems |
| Maestro Harrell | Randy Wagstaff |
| Julito McCullum | Namond Brice |
| Tristan Mack Wilds | Michael Lee |
| Gbenga Akinnagbe | Chris Partlow |
| Robert F. Chew | Joseph 'Proposition Joe' Stewart |
| Susan Duvall | Assistant Principal Marcia Donnelly |
| Dravon James | Grace Sampson |
| Melvin Williams | Deacon |
| Maria Broom | Marla Daniels |
| Brandy Burre | Theresa D'Agostino |
| Karen Vicks | Gerry |
| Alfonso Christian Lover | Old Face Andre |
| S. Robert Morgan | Butchie |
| Felicia Pearson | Felicia 'Snoop' Pearson |
| Phillip Burgess | Security Guard |
| Justin Burley | Justin |
| Rashad Orange | Sherrod |
| Boris McGiver | Lt. Charles Marimow |
| Rick Otto | Off. Kenneth Dozerman |
| Delaney Williams | Sgt. Jay Landsman |
| Shamika Cotton | Raylene Lee |
| David Fonteno | Poker Winner |
| Sheila Gaskins | Mrs. Anderson |
| Richard Hidlebird | Principal Claudell Withers |
| Dan De Luca | David Parenti |
| Della Ford | Woman |
| Cleo Reginald Pizana | Chief of Staff Coleman Parker |
| Lora Reed | Woman |
| Tyreeka Freamon | School Receptionist |
| Alan V. Poulson | Developer |
| Frederick Strother | State Delegate Odell Watkins |
| Gregory L. Williams | Det. Michael Crutchfield |
| Michael Willis | Andy Krawczyk |
| Michael Ahl | Detective |
| Tony Bailey | Charles |
| Tyrell Baker | Little Kevin |
| Joanna Becker | High Roller |
| Adrian Black | High Roller |
| Keenon Brice | Aaron 'Bug' Manigault |
| Darrell Britt-Gibson | Darius 'O-Dog' Hill |
| Jonnie Brown | Off. Eddie Walker |
| Stephanie Burden | Judy Pryzbylewski |
| Vicki Jean Clark | Train Traveler |
| Davon Cooper | Darnell Tyson |
| Dave Cooperman | High Roller |
| Sheila Cutchlow | Miss Sheperdson |
| Paul Fahrenkopf | High Roller |
| Joilet Harris | Off. Caroline Massey |
| Seth Hurwitz | Poker Player |
| Destiny Jackson-Evans | Crystal Judkins |
| Mark Joy | Ed Bowers |
| Atif Lanier | Western District Police Officer |
| James Lewis | Marvin |
| Jeffrey Lorenzo | Karim Williams |
| Rob J. Moore | Man at Boxing Match |
| Steven Moreti | Sean |
| Rakiya Orange | Charlene Young |
| Kwame Patterson | 'Monk' Metcalf |
| Nicole Pettis | Miss Reese |
| Ramon Rodriguez | Renaldo |
| Darrell M. Smith | School Officer Turner |
| Steve Staiger | Property Developer |
| Thomas W. Stewart | Train Traveler |
| Jason Wharton | Albert Stokes |