| Alan Alda | Senator Arnold Vinick |
| Stockard Channing | Abbey Bartlet |
| Kristin Chenoweth | Annabeth Schott |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Teri Polo | Helen Santos |
| Lily Tomlin | Deborah Fiderer |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| Allison Smith | Mallory O'Brien |
| John Getz | Congressman Mark B. Sellner |
| NiCole Robinson | Margaret Hooper |
| Renée Estevez | Nancy |
| Matthew Del Negro | Bram Howard |
| Karis Campbell | Ronna |
| Rob Lowe | Sam Seaborn |
| Keb' Mo' | Keb' Mo' |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Charles Noland | Reporter Steve |
| Peter James Smith | Ed |
| William Duffy | Larry |
| Jerry Cerwonka | Cardinal Doherty |
| Ann Ryerson | Chief Justice |
| Marco Martinez | Agent Darryl |
| John Balma | Cartwright |
| Kim Webster | Ginger |
| Kia Glover | Steward |
| Van Epperson | Curtis Shaeffer - Chief Usher |
| Catherine Aselford | Bonnie Kilmer |
| Chris Bloch | Man |
| Michael Ahl | Secret Service |
| Brian Dragonuk | Democratic Party VIP |
| Alan Gray | VIP Guest |
| Kamal Jones | Congressional Staffer |
| James McMann | Inauguration Guest |
| Nora Paradiso | Inaugural Guest |
| Aaron Sorkin | Man in Crowd |
| Schuster Vance | Senator Wirth |
| Anthony Wanzer | Secret Service Agent |
| George F. Watson | Secret Service President Bartlett's Final White House Escort |