| Alan Alda | Senator Arnold Vinick |
| Kristin Chenoweth | Annabeth Schott
(credit only) |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey
(credit only) |
| Mary McCormack | Kate Harper
(credit only) |
| Janel Moloney | Donna Moss
(credit only) |
| John Spencer | Leo McGarry
(credit only) |
| Bradley Whitford | Josh Lyman
(credit only) |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet
(credit only) |
| Mary-Louise Parker | Amy Gardner |
| Teri Polo | Helen Santos |
| Patricia Richardson | Sheila Brooks |
| Janeane Garofalo | Louise Thornton |
| Stephen Root | Bob Mayer |
| Michael O'Neill | Secret Service Agent Ron Butterfield |
| John Aylward | Barry Goodwin - Head of Transition |
| NiCole Robinson | Margaret Hooper |
| David Clennon | Jim - Vinick's Attorney |
| Karis Campbell | Ronna |
| Marlene Forte | Secret Service Agent Linda |
| Bonita Friedericy | Gail Addison |
| Adrian Sparks | Dr. Wexler |
| Ashlyn Sanchez | Miranda Santos |
| Joshua Cabrera | Peter Santos |
| Annie Morgan | Annie |
| Paul Keeley | Agent Ellis Taylor |
| Ivan Allen | News Anchor Roger Salier |
| Van Epperson | Curtis Shaeffer - Chief Usher |
| Alexandra Ryan | Receptionist |
| Parvesh Cheena | Barista |
| Maria Broom | Cathy Holland |
| Monica Cabral | (uncredited) |
| Enrique Chicas | President's Steward at Camp David
(uncredited) |
| Kaleigh Kailani | Vinick Granddaughter
(uncredited) |
| Summer Kailani | Vinick Granddaughter
(uncredited) |
| Ken-Ali | Santos Staffer
(uncredited) |
| Aaron Michael Lacey | Secret Service Agent
(uncredited) |
| Manuel Poblete | Secret Service Agent
(uncredited) |