| Alan Alda | Senator Arnold Vinick
(credit only) |
| Stockard Channing | Abbey Bartlet |
| Kristin Chenoweth | Annabeth Schott
(credit only) |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper |
| Janel Moloney | Donna Moss |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Janeane Garofalo | Louise Thornton |
| Lily Tomlin | Deborah Fiderer |
| Nina Siemaszko | Ellie Bartlet |
| Ben Weber | Vic Faison - Ellie's Fiancé |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| John Aylward | Barry Goodwin - Former DNC Chair |
| Robert Foxworth | Senator George Montgomery |
| Matthew Del Negro | Bram Howard |
| Diana Maria Riva | Edie Ortega
(as Diana-Maria Riva) |
| Richard Jenik | Congressman Cooper |
| Melissa Fitzgerald | Carol Fitzpatrick |
| Jan Devereaux | Shirley - Social Secretary |
| Ron Ostrow | Reporter John |
| Joyce Guy | Reporter Charlayne |
| Dougald Park | Stan Mitchell - Chicago DNC |
| Yvans Jourdain | Bermudan Ambassador |
| Linden Goh | Translator |
| Bill Blair | Congressman
(uncredited) |
| David Garrison | Mike Diacovo - MSNBC Talking Head
(uncredited) |
| Lindsay Stuart | Maid of Honor
(uncredited) |
| Jaime A. Timsit | Flowergirl
(uncredited) |