| Stockard Channing | Abbey Bartlet
(credit only) |
| Dulé Hill | Charlie Young |
| Allison Janney | C.J. Cregg |
| Joshua Malina | Will Bailey |
| Mary McCormack | Kate Harper
(credit only) |
| Janel Moloney | Donna Moss |
| Richard Schiff | Toby Ziegler |
| John Spencer | Leo McGarry |
| Bradley Whitford | Josh Lyman |
| Jimmy Smits | Matthew Santos |
| Martin Sheen | President Josiah Bartlet |
| Kristin Chenoweth | Annabeth Schott |
| Lily Tomlin | Deborah Fiderer |
| Anna Deavere Smith | Nancy McNally |
| Steve Ryan | Secretary of Defense Miles Hutchinson |
| NiCole Robinson | Margaret Hooper |
| Melissa Fitzgerald | Carol Fitzpatrick |
| David Shatraw | Ed Merridy |
| David Kelsey | Staff Sergeant Keltie |
| Eugene Alper | Roman Mindeli |
| Andrew Borba | Alan Zwick |
| Ron Ostrow | Reporter John |
| Timothy Davis-Reed | Mark O'Donnell |
| Mindy Seeger | Chris |
| Beau Billingslea | Agent Caswell |
| Evan Arnold | Ned |
| Karis Campbell | Ronna |
| Armando Valdes-Kennedy | Dave |
| Gregory Wagrowski | Dan Edmunds |
| Katherine Disque | Claire Stein |
| Bill Birch | Len Segal |
| Terry Bozeman | Energy Secretary Gerald Deloit |
| Wayne Thomas Yorke | Chris Lakely |
| David Hadinger | Donald Donchick |